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Blast Vitrification
David Hickman said on 06 June 2010
"Day 5 blasts tend to produce a higher pregnancy rates and I think several papers have shown this. However, day 6 blasts can work and even though there may be a lower rate for whatever reason...why not freeze them if they can produce a pregnancy. Some places actually freeze up to day 7 but we do not. If the blasts are going so slow that they do not reach a good blast stage by day 7 with a good culture system, something is not quite right and i do not want to risk freezing or transferring them. It seems the earlier or the more compact the blast, the better it survives. Some papers have shown that mechanically shrinking an expanding blast actually increases it's survival chances. Also,I have actually vitrified fully hatched blasts on patients that either chose not to freeze or on ones that were abnormal from PGD. It's a tossup and there is not a definate prediction as to what will survive. Some will and some won't. However, when I used slow freeze...there were few if any that survived a freeze after hatching. Vitrification is the way to go."
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Triantafillos Triantafillou said on 27 January 2010
"The sooner the better. Blastocysts that have not expanded too much tend to survive better.
For fully expanded blastocysts, forcing them mechanically to collapse may be a good idea.
I have no idea how hatched blastocysts survive vitrification, I have never tried it."
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