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SARITHA KR said on 09 March 2009
"We had same type of case. By IVF, fertilization and cleavage occurred. But all blastomeres were dark brown in colour. ET cancelled. On subsequent cycle by ICSI, we could get best embryos and ET done. She is pregnant carrying twin gestation. Some seminal factors probably the cause for such dark blastomeres. In whatever way sperm is harvested, some seminal factors may persist in final preparation. When you are doing IVF, there are higher chances for such factors to be in contact with oocytes. One important note to make is this particular male patient was under anti alcoholic treatment when he came for the first cycle.
Dr. Saritha KR"
Reply
Brownish zygotes
Dr.Ravindranath said on 19 February 2009
"In unexplained Infertility cases, there shall be some hidden problems or pathology which may creat such problems. In such cases, ICSI is the better option and assisted hatching may also help. The brownish zona shows the patient might have a history of endometriotic cysts in some of her cycles. The endometriosis needs to be ruled out. Try to use recombunant FSH instead of urinary gonadotrophins.
Good luck"
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