IVF Mail - flushing medium with or without heparin?

flushing medium with or without heparin?

By: Wendy,
27 June 2008


Question:
	The main use of heparin is to avoid the blood clot during the oocyte retrieval procedure. Does anyone use flushing medium without heparin in their procedure? Any effect on fertilization rate in IVF?

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Shantal Rajah said on 17 July 2008

"Wendy, we did use heparin in the past (6yrs ago) as you mentioned and feared for cloting while aspiration. Now I do not use heparin in flush medium and I did not find any difference in finding any clots or in collecting eggs or fertilisation rate or pregnancy rate. I think it is safe to stop using in your fulushing medium."

hisham ibrahim said on 13 July 2008

"NO it does not affect the fertilization or the divisions later.we do not use heparine in ours and we have a very good results"

Weihua Wang said on 01 July 2008

"We never use heparin in our flushing medium and never have problem."

alok teotia said on 30 June 2008

"presence of heparin only delays the clot formation for a small time, if you are screening the follicular aspirate at the same time then, probably you dont need it."

Wendy said on 28 June 2008

"I don't know whether any contaminated heparin in UK. But I just wonder if there is no heparin in the flushing medium, blood clot occurs and end-up is the clot blood attached in the oocyte and affect the fertilization in IVF and also increase the difficulty of oocyte finding. I ask, cos' heparin is stopped to use in our centre cos' of complicated supplier procedure. I am only a small potato and I don't know it does adverse effect or not, so I post this question and ask any expertist opinions. Thanks."

paula woodward said on 27 June 2008

"Any UK clinician responding to this question should first read the recent HFEA alert about heparin. This was issued following alerts issued by the MHRA.
Please note, UK clinics must login to the HFEA site to view this alert. www.hfea.gov.uk
The MHRA alerts can be viewed here: http://www.mhra.gov.uk/Publications/Safetywarnings/Drugalerts/CON014890"