IVF Mail - High prolactin and infertility

High prolactin and infertility

By: Shane,
05 May 2007


Question:
	What are the reasons for high prolactin in women? As a infertility specialist, Iam extremely surprised that many of my patients who come to me with infertility issues have high prolactin and mostly accompanied by hypothyroidism. Is it a feature of hot climate or lifestyle patterns in the Middle Easern countries. I have noticed this irrespective of age or race. How can high prolactin be treated other than through medications?

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Alok Teotia said on 14 September 2007

"i totally agree with Dr David Robertson
prolactin may increase because of procedural stress, slight increase seems to have no significance, however prolactin secreting tumors must me ruled out if there is some suspicion."

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Tracy said on 16 October 2011

"Have you considered a drop in dopamine? It can cause increased prolactin and can contribute to hypothyroidism. Many women respond to high protein diet or protein shakes...possibly due to the inclusion of L-tyrosine (precursor to dopamine). Or they also can take L-tyroisine supplements alone. Second consideration is that many infertile women also take DHEA or L-argenine to possibly help with egg quality, both of which can increase prolactin....and probably also decrease dopamine."

Dr David Robertson said on 06 June 2007

"First of all, define what you mean by a high prolactin level. One thing I notice particularly since I came to work in the Gulf, is the number of women being treated for "hyperprolactinaemia" who don't need to be. A marginal elevation can often be discounted - less than 1000 U/L or 23ng/ml can usually be ignored.Certain drugs may elevate prolactin, as will anxiety (someone coming towards you with a needle and syringe!)and, of course, hypothyroidism / raised TSH.You also need to ask your lab what proportion is macroprolactin and biologically active.

You will then find that a true elevation is not that common."

DPankar Banerji said on 27 May 2007

"Hypothyroidism means high TSH.High prolactin levels are common with high TSH.But the prolactin levels are marginally high. Treat by thyroxin eg.100mic gm/day for atleast 15 days and correct the TSH level ( here 0.5 to 5.0 mIU/ml ).Then do prolactin ,it might get corrected.Bye"

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