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Stress can enhance chemical damage to male fertility

[BioNews, London]

Exposure to a combination of excessive stress and everyday chemicals whilst in the womb can have implications for future male fertility, according to Dr Amanda Drake and colleagues from the Centre for Cardiovascular Science and Reproductive Biology at the Queen's Medical Research Institute, University of Edinburgh.

Undescended testicles (cryptorchidism), misaligned urinary tracts (hypospadias) and low sperm counts are becoming much more common. Drake and her team link these three conditions to a syndrome called testicular dysgenesis syndrome (TDS), saying this is the result of reduced production or action of male sex hormones during a critical period of development.

Previous studies have found that between eight and 12 weeks into pregnancy is a crucial period for male reproductive development. During this timeframe, testosterone is produced, which affects development of male reproductive organs and fertility in later life.

Dr Drake and her group injected pregnant rats within this gestation period with either chemicals called phthalates; these are solvents used to soften plastic and can be found in a whole range of household products including shower curtains, credit cards and even children's toys, a stress hormone called dexaethasone or a combination of the two treatments.

The results, published in the journal Endocrinology, showed that giving the phthalates alone had an effect on fertility, whilst the stress hormone on its own did not. However, the researchers noted there was a further increase in fertility problems if the mother had been injected with both the stress hormone and the plastic chemical.

Drake has said these results could perhaps explain the reported recent increase in male infertility, as it takes into account chemical compound implications in conjunction with increases in stressful lifestyle factors.

'What the study shows is that it is not simply a case of one factor in isolation contributing to abnormalities in male development but a combination of both lifestyle and environmental factors, which together have a greater impact, Our study suggests that additional exposure to stress, which is a part of everyday life, may increase the risk of these disorders and could mean that lower levels of chemicals are required to cause adverse affects'.

Reproduced with permission from BioNews, an email and online sources of news, information and comment on assisted reproduction and genetics.