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According to OECD Guidelines for Testing of Chemicals, Test No. 490, the in vitro mouse lymphoma assay (MLA) is used to detect induced point mutations or clastogenic events of the thymidine kinase (TK) locus of L5178Y TK+/– mouse lymphoma cells by measuring resistance to the lethal nucleoside analogue triflurothymidine (TFT).
STEMart provides in vitro mouse lymphoma assay to assess the capacity of leachable from a medical device to induce gene mutations or chromosomal events. This assay is available under either GLP (Good Laboratory Practice) or Non-GLP conditions.
